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1

Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C

Giorgio Caravatti, Thomas Meyer, Andreas Fredenhagen, Uwe Trinks, Helmut Mett, Doriano Fabbro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 440 KB

english, 1994

2

Different Susceptibility of Protein Kinases to Staurosporine Inhibition : Kinetic Studies and Molecular Bases for the Resistance of Protein Kinase CK2

Flavio Meggio, Arianna Donella Deana, Maria Ruzzene, Anna M. Brunati, Luca Cesaro, Barbara Guerra, Thomas Meyer, Helmut Mett, Doriano Fabbro, Pascal Furet, Grazyna Dobrowolska, Lorenzo A. Pinna

Journal:

Year:

1995

Language:

english

File:

PDF, 743 KB

english, 1995

3

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4- d ]pyrimidines

Traxler, Peter, Bold, Guido, Frei, Joerg, Lang, Marc, Lydon, Nicholas, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Mueller, Marcel, Furet, Pascal

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 387 KB

english, 1997

4

A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo

Nicholas B. Lydon, Helmut Mett, Marcel Mueller, Michael Becker, Robert M. Cozens, David Stover, Daren Daniels, Peter Traxler, Elisabeth Buchdunger

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 243 KB

english, 1998

5

Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

Jürg Zimmermann, Giorgio Caravatti, Helmut Mett, Thomas Meyer, Marcel Müller, Nicholas B. Lydon, Doriano Fabbro

Journal:

Archiv der Pharmazie

Year:

1996

Language:

english

File:

PDF, 589 KB

english, 1996

6

ChemInform Abstract: 2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors.

Patricia Imbach, Hans-Georg Capraro, Pascal Furet, Helmut Mett, Thomas Meyer, Juerg Zimmermann

Journal:

Year:

1999

File:

PDF, 29 KB

1999

7

ChemInform Abstract: Substituted 5,7-Diphenyl-pyrrolo[2,3-d]pyrimidines: Potent Inhibitors of the Tyrosine Kinase c-Src.

Martin Missbach, Eva Altmann, Leo Widler, Mira Susa, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Jonathan Green

Journal:

Year:

2000

File:

PDF, 30 KB

2000

8

Nitrostyrene Derivatives of Adenosine 5′-Glutarates as Selective Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase

Stefan Peterli, Regina Stumpf, Marc Schweizer, Urs Séquin, Helmut Mett, Peter Traxler

Journal:

Helvetica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 751 KB

english, 1992

9

Nitrostyrene Derivatives of Adenosine 5′-Glutarates Modified with an Alkyl Spacer and their inhibitory activity on epidermal growth factor receptor protein tyrosine kinase

Stefan Peterli, Dieter Hubmann, Urs Séquin, Helmut Mett, Peter Traxler

Journal:

Helvetica Chimica Acta

Year:

1994

Language:

english

File:

PDF, 796 KB

english, 1994

10

Synthesis of Modified Tripeptides and Tetrapeptides as potential bisubstrate inhibitors of the epidermal growth factor receptor protein tyrosine kinase

Gérard Rossé, Urs Séquin, Helmut Mett, Pascal Furet, Peter Traxler, Heinz Fretz

Journal:

Helvetica Chimica Acta

Year:

1997

Language:

english

File:

PDF, 1.00 MB

english, 1997

11

Determination of Decarboxylase Activity in Adherent Tissue Culture Cells

Barbara Schacher, Robert Reuter, Katrin Bussell, Helmut Mett

Journal:

Analytical Biochemistry

Year:

1996

Language:

english

File:

PDF, 76 KB

english, 1996

12

Phenylamino-pyrimidine (PAP) — derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors

Jürg Zimmermann, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Nicholas B. Lydon, Peter Traxler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 316 KB

english, 1996

13

Corrigendum to “2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors”: (Bioorg. Med. Chem. Lett. 1999, 9, 91–96)

Patricia Imbach, Hans-Georg Capraro, Pascal Furet, Helmut Mett, Thomas Meyer, Jürg Zimmermann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 61 KB

english, 2000

14

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src

Martin Missbach, Eva Altmann, Leo Widler, Mira Šuša, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Jonathan Green

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 6.06 MB

english, 2000

15

Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

Jürg Zimmermann, Elisabeth Buchdunger, Helmut Mett, Thomas Meyer, Nicholas B. Lydon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 279 KB

english, 1997

16

2,6,9-trisubstituted purines : Optimization towards highly potent and selective CDK1 inhibitors

Patricia Imbach, Hans-Georg Capraro, Pascal Furet, Helmut Mett, Thomas Meyer, Jürg Zimmermann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 348 KB

english, 1999

17

Reviews

Max Sparreboom, Nicholas Sims-Williams, D. N. Mackenzie, R. K. Barz, Per Kvaerne, Adelheid Mette, Royce Wiles, J. W. De Jong, Helmut Eimer

Journal:

Indo-Iranian Journal

Year:

1986

Language:

english

File:

PDF, 1.93 MB

english, 1986

18

Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues

Helmut Mett, Jaroslav Stanek, Juan A. Lopez-Ballester, Juhani Jänne, Leena Alhonen, Riita Sinervirta, Jörg Frei, Urs Regenass

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1993

Language:

english

File:

PDF, 932 KB

english, 1993

19

Opsonin-dependent phagocytosis of bacteria by murine macrophage-like cells

Helmut Mett, Lydie Kloetzlen, J. Hinrich Peters

Journal:

Current Microbiology

Year:

1986

Language:

english

File:

PDF, 1.02 MB

english, 1986

20

Michaelis-Menten kinetic analysis of Escherichia coli SS142 adhesion to intestine 407 monolayers

Paul S. Cohen, Alan D. Elbein, Renate Solf, Helmut Mett, Janos Regös, Eva Brigitte Menge, Klaus Vosbeck

Journal:

FEMS Microbiology Letters

Year:

1981

Language:

english

File:

PDF, 334 KB

english, 1981

21

The effects of cefotaxime and mecillinam on the terminal stages of Escherichia coli peptidoglycan synthesis

Helmut Mett, David Mirelman

Journal:

FEMS Microbiology Letters

Year:

1983

Language:

english

File:

PDF, 387 KB

english, 1983

22

Inhibitors of Protein Kinases: CGP 41251, a Protein Kinase Inhibitor with Potential as an Anticancer Agent

Doriano Fabbro, Elisabeth Buchdunger, Jeannette Wood, Jürgen Mestan, Francesco Hofmann, Stefano Ferrari, Helmut Mett, Terence O’Reilly, Thomas Meyer

Journal:

Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 239 KB

english, 1999

23

MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus

Akram A Da’dara, Helmut Mett, Rolf D Walter

Journal:

Molecular and Biochemical Parasitology

Year:

1998

Language:

english

File:

PDF, 116 KB

english, 1998

24

Large-scale purification and characterisation of a recombinant epidermal growth-factor receptor protein-tyrosine kinase : Modulation of activity by multiple factors

Elaine McGLYNN, Michael BECKER, Helmut METT, Sarah REUTENER, Robert COZENS, Nicholas B. LYDON

Journal:

Year:

1992

Language:

english

File:

PDF, 1.23 MB

english, 1992

25

S-Adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogs of methylglyoxal bis(guanylhydrazone)

Stanek, Jaroslav, Caravatti, Giorgio, Capraro, Hans Georg, Furet, Pascal, Mett, Helmut, Schneider, Peter, Regenass, Urs

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.10 MB

english, 1993

26

New Cationic Lipids Form Channel-Like Pores in Phospholipid Bilayers

Chanturiya, Alexandr, Yang, Jingping, Scaria, Puthupparampil, Stanek, Jaroslav, Frei, Joerg, Mett, Helmut, Woodle, Martin

Journal:

Biophysical Journal

Year:

2003

Language:

english

File:

PDF, 285 KB

english, 2003

27

2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity

Stanek, Jaroslav, Frei, Joerg, Mett, Helmut, Schneider, Peter, Regenass, Urs

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 733 KB

english, 1992

28

Use of a Pharmacophore Model for the Design of EGFR Tyrosine Kinase Inhibitors: Isoflavones and 3-Phenyl-4(1 H )-quinolones

Traxler, Peter, Green, Jennifer, Mett, Helmut, Séquin, Urs, Furet, Pascal

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 180 KB

english, 1999

29

4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Traxler, Peter M., Furet, Pascal, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Lydon, Nicholas

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 274 KB

english, 1996

30

4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-adenosylmethionine decarboxylase

Stanek, Jaroslav, Caravatti, Giorgio, Frei, Jorg, Furet, Pascal, Mett, Helmut, Schneider, Peter, Regenass, Urs

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 552 KB

english, 1993

31

[(Alkylamino)methyl]acrylophenones: Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase

Traxler, Peter, Trinks, Uwe, Buchdunger, Elisabeth, Mett, Helmut, Meyer, Thomas, Mueller, Marcel, Regenass, Urs, Roesel, Johannes, Lydon, Nicholas

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

32

Dianilinophthalimides: Potent and Selective, ATP-Competitive Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Trinks, Uwe, Buchdunger, Elisabeth, Furet, Pascal, Kump, Wilhelm, Mett, Helmut, Meyer, Thomas, Mueller, Marcel, Regenass, Urs, Rihs, Greti

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.49 MB

english, 1994

33

Penems: In Vitro and In Vivo Experiments

Zak, Oto, Lang, Marc, Cozens, Robert, Konopka, Edward A., Mett, Helmut, Schneider, Peter, Tosch, Werner, Scartazzini, Riccardo

Journal:

Journal of Clinical Pharmacology

Year:

1988

Language:

english

File:

PDF, 951 KB

english, 1988

34

A Revision of Corded Ware Settlement Pattern –New Results from the Central European Low Mountain Range.

Müller, Johannes, Seregély, Timo, Becker, Cornelia, Christensen, Anne-Mette, Fuchs, Markus, Kroll, Helmut, Mischka, Doris, Schüssler, Ulrich

Journal:

Proceedings of the Prehistoric Society

Year:

2009

Language:

english

File:

PDF, 2.52 MB

english, 2009

35

Ultrasonic disintegration of bacteria may lead to irreversible inactivation of β-lactamase

Mett, Helmut, Schacher, Barbara, Wegmann, Lukas

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1988

Language:

english

File:

PDF, 310 KB

english, 1988

36

Selective Inhibition of the Platelet-Derived Growth Factor Signal Transduction Pathway by a Protein-Tyrosine Kinase Inhibitor of the 2- Phenylaminopyrimidine Class

Elisabeth Buchdunger, Jurg Zimmermann, Helmut Mett, Thomas Meyer, Marcel Muller, Urs Regenass and Nicholas B. Lydon

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.13 MB

english, 1995

37

4,5-Dianilinophthalimide: A Protein-Tyrosine Kinase Inhibitor with Selectivity for the Epidermal Growth Factor Receptor Signal Transduction Pathway and Potent in vivo Antitumor Activity

Elisabeth Buchdunger, Uwe Trinks, Helmut Mett, Urs Regenass, Marcel Muller, Thomas Meyer, Elaine McGlynn, Lorenzo A. Pinna, Peter Traxler and Nicholas B. Lydon

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.16 MB

english, 1994

38

Reviews

Eimer, Helmut, Wiles, Royce, Kvaerne, Per, De Jong, J. W., Mackenzie, D. N., Mette, Adelheid, Sparreboom, Max, Barz, R. K., Sims-Williams, Nicholas

Journal:

Indo-Iranian Journal

Year:

1986

Language:

english

File:

PDF, 268 KB

english, 1986

39

CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme

SVENSSON, Fredrik, METT, Helmut, PERSSON, Lo

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 336 KB

english, 1997

40

Protein Tyrosine Kinase and Protein Kinase C Inhibition by Fungal Anthraquinones Related to Emodin.

FREDENHAGEN, ANDREAS, METT, HELMUT, MEYER, THOMAS, BUCHDUNGER, ELISABETH, REGENASS, URS, ROGGO, BARBARA E., PETERSEN, FRANK

Journal:

The Journal of Antibiotics

Year:

1995

Language:

english

File:

PDF, 304 KB

english, 1995

41

Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the Fungus Chrysosporium merdarium.

FREDENHAGEN, ANDREAS, PETERSEN, FRANK, TINTELNOT-BLOMLEY, MARINA, RÖSEL, JOHANNES, METT, HELMUT, HUG, PAUL

Journal:

The Journal of Antibiotics

Year:

1997

Language:

english

File:

PDF, 518 KB

english, 1997

42

Paeciloquinones A,B,C,D,E and F: New Potent Inhibitors of Protein Tyrosine Kinases Produced by Paecilomyces carneus. I. Taxonomy, Fermentation, Isolation and Biological Activity.

PETERSEN, FRANK, FREDENHAGEN, ANDREAS, METT, HELMUT, LYDON, NICHOLAS B., DELMENDO, RON, JENNY, HANS-BEAT, PETER, HEINRICH H.

Journal:

The Journal of Antibiotics

Year:

1995

Language:

english

File:

PDF, 552 KB

english, 1995

43

Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to These include : Alterations in Ornithine Decarboxylase Characteristics Account for Tolerance of Trypanosoma brucei rhodesiense to D , L - ␣ -

Iten, M, Mett, H, Evans, a, Enyaru, J C, Brun, R, Kaminsky, R, Iten, Monika, Mett, Helmut, Evans, Amanda, Enyaru, John C K, Brun, Reto

Year:

1997

Language:

english

File:

PDF, 295 KB

english, 1997

44

The impact of different scenarios for intermittent bladder catheterization on health state utilities: results from an internet-based time trade-off survey

Averbeck, Márcio Augusto, Krassioukov, Andrei, Thiruchelvam, Nikesh, Madersbacher, Helmut, Bøgelund, Mette, Igawa, Yasuhiko

Journal:

Journal of Medical Economics

Year:

2018

Language:

english

File:

PDF, 890 KB

english, 2018